Make sure you have a good ground on the amp.. If there is not a good ground you'll get a winding noise especially when you accelerate

You are experiencing a ground loop which causes the whining noise that reacts to the throttle/alternator. This could be a bad ground (non clean metal) or if you run the rca cable along side the power wire the rca can pick up interference from the power wire more common in less quality shielding in the rcas. Usually when only running a sub amp you wouldn't notice the interference but since you are running mids n highs amp it is noticeable. Try cleaning grounds at amp and battery and the location how you route the rcas. I usually run them down separate sides..or they make a ground loop isolator that plugs inline with the rcas but those dont always work. Sorry for long msg but to test you can jump a ground wire to the shielding part of the rca which is the outermost part of the connection not the center prong. Again sorry and thank you for your time, Jason Penny

You might find relief by installing a capacitor to filter the noise out.

This is absolutely a ground issue and the most common reason for engine whine in a sound system. Metal to metal ground connection and RCA cables ran down one side of the car and power down the other fixes this issue 80% of the time. Sometimes it can be caused by a weak connection in the radio ground as well, but not too common.

As far as the speaker rattle at high volume throw some dynamat around them and make sure they are very securely screwed in. Sometimes the plastic where they mounting screws go gets warped and makes the mounting a little sketch.