It's simple...
-Larger fuel pump
-AFPR
-Big injectors
-Something to tune it with
I have a friend (Patter$on on here) that converted his '99 GSX to e85 using a Walbro 255, AFPR, 1000cc injectors, and DSMLink. He's run 12.2 so far on a E316G. Being that it is 105 octane and cheaper at the pump than regular gas, he can make race gas power for cheaper than pump gas prices! He lives in Oregon and the price for e85 is $2.35/gal. versus the $2.70+ for regular gas.
And all of that crap about the e85 corroding rubber fuel lines and destroying your gas tank and fuel rail is a bunch of crap. Most people upgrade their fuel lines when making big power anyway, but it isn't necessary. My other friend with a 500hp Galant VR-4 runs e85 daily and when he pulled his head after 10000 miles of straight e85 use, there wasn't a single bit of carbon build up on his valves or pistons.
http://www.e85fuel.com/